In a comprehensive comparison of soluble factors in tumour and xenograft tissue, a range of human pro- and anti-inflammatory factors was detected in the primary medulloblastoma, whereas only IL-8, IL-16 and VEGFA were seen in cultured cells and xenografts, suggesting that most cytokines in the primary tissue were stromal-derived. This evidence concerns the gene CXCL8 and medulloblastoma.