SLC6A3 and SLC6A3-related dopamine transporter deficiency syndrome: As seen in the majority of DTDS patients at early stages, DAT-KO mice display hyperkinesia starting from 3–4 weeks of age, and as in later stages of DTDS, more than 30% of these hyperactive mice progressively develop motor deficits and loss of hyperactivity, signs of striatal neurodegeneration and increased mortality5, 17, 18.