USP22 and neoplasm: Remarkably, silencing USP22 reduced the tumor volume of BEL/FU cells treated with 5‐FU (BEL/FU control shRNA cells treated with 5‐FU vs BEL/FU USP22 shRNA treated with 5‐FU, 945 ± 545 mm3 vs 372 ± 228 mm3, P < 0.05).