SIRT1 and neurodegenerative disease: Notably, sirtuin 1 (SIRT1), a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD+)‐dependent class III histone deacetylases that are human homologues of yeast silent information regulator 2, controls a variety of biologic processes ranging from metabolic homeostasis, neurodegenerative diseases, and aging to cancer (Armour et al., 2013).