Cheong et al. reported that circadian genes (Clock and Bmal1) were elevated in the ovaries of 15-week-old C57BL/6J mice from HF-fed dams, whereas lower expression levels of Cry1 and Per1 were observed in offspring exposed to HF nutrition throughout life, which preserved the circadian gene phase-related expression pattern [11]. Here, CLOCK is linked to hydrops fetalis.