GGH and neoplasm: We previously reported that the tumor expression levels of folate-related genes, such as folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), and of 5-FU-related genes, such as thymidine phosphorylase (TYMP), thymidylate synthetase (TYMS), and dihydropyrimidine dehydrogenase (DPYD), are closely correlated with the response to preoperative chemotherapy or chemoradiotherapy including UFT or S-1 [8, 22–24].