TP53 and cancer: Despite the fact that the mutated form of p53 gene may provide a more favourable condition for reprogramming cancer cells (Ebrahimi, 2015; Vierbuchen & Wernig, 2012; Spike & Wahl, 2011), the presence rather than the absence of the mutant p53 expression has been reported to enhance reprogramming efficiency (Sarig et al., 2010; Tapia & Schöler, 2010) as in the case of H103 which was able to maintain its pluripotent features under prolonged passage.