KLF4 and cancer: As Klf4 is known to act either as a tumour suppressor gene or an oncogene, depending on the need of the tumour cells and the types of cancer (Evans & Liu, 2008) and c-Myc is a crucial oncogene that confers immortality in cancer cells via a shift from senescence state to oncogenic progression (Erenpreisa & Cragg, 2013), these transcription factors have been highly implicated in influencing cancer progression.