Hyper-methylation of NOS1AP promoter is shown to be associated with intracranial aneurysm and brain arteriovenous malformation as a result of regular tobacco use [39] NOS1AP has been implicated in several human neurodegenerative diseases, such as cardiovascular disorders (stroke), psychiatric disorders, and post-traumatic stress disorders [40]. The gene discussed is NOS1AP; the disease is neurodegenerative disease.