AKT1 and mantle cell lymphoma: Mechanistically, western blot and flow cytometry revealed higher β1 expression, AKT/4EBP phosphorylation in xenografted MCL tumors from mice receiving HK and HBL-2 cells and in xenografted MCL tumors in mice receiving IR HBL-2 cells compared with those receiving HBL-2 cells only or parental cells (Fig. 6b).