Nevertheless, VLP-1 had pathologically referred to molecular mechanisms of AD by correlation with amyloid precursor protein expression, which led to Ab deposition and neurodegeneration.23,24 Furthermore, positive correlation between VLP-1 levels and amyloid load in the brain had been revealed by a study of amyloid neuroimaging in vivo.22 Therefore, increasing t-tau and decreasing Ab42 related to CSF VLP-1 levels in CSF of AD patients relative to healthy controls and MCI patients. This evidence concerns the gene APP and Alzheimer disease.