Interestingly, consistent with blue staining, we validated the loss of EZH2 enrichment in mutant exogenous METTL7A template compared to wild type template in cancer cell line, which indicated that METTL7A had a special methylation motif (central at +4919 CpG site) recognized by EZH2 at the gene body. This evidence concerns the gene EZH2 and cancer.