SLC26A2, FKBP5, KRT19, SORD, HOMER2, NDRG1, TPD52, INPP4B, PTPN21, ZMIZ1, PMEPA1, PPAP2A, TSC22D1, ACSL3, KLK3, NKX3-1, ELL2, MAP7, PTK2B, SMS, SPDEF, ABCC4, KLK2, MAF, TARP, AZGP1, and TMPRSS2 were key regulators of prostate cancer and AR signaling based on the KDM3A ChIP-Seq data (Figure 2A–2B). The gene discussed is SPDEF; the disease is Familial prostate cancer.