Interestingly, high ZEB1 expression was significantly associated with large tumor size (pooled OR for ZEB1: 1.571, 95% CI: 1.162-2.124, p=0.003; pooled OR for ZEB2: 1.318, 95% CI: 0.888-1.956, p=0.171) and poor differentiation (pooled OR for ZEB1: 2.428, 95% CI: 1.644-3.578, p<0.001; pooled OR for ZEB2: 1.068, 95% CI: 0.159-7.146, p=0.946), while ZEB2 did not show the same effect. Here, ZEB1 is linked to neoplasm.