CHRM3 and cancer: Although the mean fold-change in MMP1 mRNA level in cancers with increased CHRM3 expression (samples 9–18) was almost 10-fold greater than those in cancers with reduced CHRM3 expression (samples 1–7) (MMP1 mRNA fold-change, 1042.5 ± 711.0 vs 119.5 ± 60.8; mean ± SE), due to considerable inter-sample variation and large standard errors this difference failed to achieve statistical significance.