HCC patients with tumors bearing mutant TERT promoter exhibited remarkably lower frequencies of rs2736098_TT and rs2736100_CC genotypes compared with those of healthy controls (Table 3) (mutant cases vs controls: 3.6% vs 12.9% and 5.8 vs 25.3% for rs2736098_TT and rs2736100_CC, respectively). The gene discussed is TERT; the disease is hepatocellular carcinoma.