As evidence of this, we demonstrated a significant tumor shrinkage of those tumors resistant to first-generation EGFR-TKIs by using second-generation inhibitors and of those tumors resistant to first- and second-generation EGFR-TKIs with the use of the third-generation inhibitor osimertinib, suggesting that keeping EGFR blockade may represent a valid option of treatment at progression. Here, EGFR is linked to neoplasm.