Foretinib resulted a stronger inhibitor of cell proliferation as compared to sonidegib; however the combined treatment of sonidegib or foretinib with osimertinib significantly inhibited cancer cells abilities with a superiority of the combination of foretinib and osimertinib, while the combined blockade of SMO and AXL resulted only in an additive effect (Figure 6B). The gene discussed is AXL; the disease is cancer.