EGFR and non-small cell lung carcinoma: Tumors containing activating EGFR mutations (deletion in exon 19 or an L858R point mutation), which account for about 16% of advanced NSCLC patients, result sensitive to the first- and second-generation EGFR tyrosine kinase inhibitors (EGFR-TKIs) gefitinib, erlotinib, and afatinib, respectively [1, 2].