Inactivation of the destruction complex, either through WNT stimulation or, as occurs in CRC cells, inactivation of APC, results in not only β-catenin but also TAZ/YAP stabilization and the opportunity for TAZ/YAP to translocate to the nucleus (Azzolin et al., 2012, Azzolin et al., 2014). Here, APC is linked to colorectal carcinoma.