Similar to HEK293 and HaCaT cells (Figures 4C and S4E–S4G), TIAM1 depletion in SW620 and DLD1 cells strongly induced the expression of CTGF and CYR61, which could be suppressed by depletion of endogenous YAP and TAZ (Figures 6D and S6C), indicating that TIAM1 inhibits the transcriptional activity of YAP and TAZ in CRC cells. The gene discussed is CCN1; the disease is colorectal carcinoma.