In keeping, TAZ/YAP are required for the overgrowth of intestinal crypts and formation of adenomas following APC inactivation (Azzolin et al., 2014, Gregorieff et al., 2015) and TAZ/YAP expression is associated with poor prognosis of CRC patients (Wang et al., 2013, Yuen et al., 2013). Here, WWTR1 is linked to colorectal carcinoma.