In the univariate analysis, we found a higher risk of developing hematological cancer in patients receiving corticosteroids (HR 2.67; p < 0.001) or an immunosuppressive agent (HR 2.83; p < 0.001), although the multivariate analysis adjusted for the main prognostic factors identified (anemia, monoclonal gammopathy, cryoglobulins, low C3, low C4, and ESSDAI) showed only non-significant differences. The gene discussed is C4A; the disease is hematopoietic and lymphoid cell neoplasm.