EIF4E and breast cancer: Indeed, Graff et al. [18] reported that intravenous eIF4E-specific antisense oligonucleotides administration in nude mice bearing PC-3 human prostate cancer or MDA-MB-231 human breast cancer xenografts, significantly suppressing tumor growth without eliciting toxicity, and also inhibited the formation of vessel-like structures by cultured human endothelial cells.