PIM1 and acute lymphoblastic leukemia: When LCK inhibitor (50 nM) was combined with AZD1208 (1 μM), we also observed synergistic inhibition of cell growth (Figure 5E–5F) and induction of apoptosis (Figure 5G–5H) in PIM inhibitor sensitive H-SB2 (CI = 0.68544) and DU.528 (CI = 0.68285) cells, suggesting the importance of this tyrosine kinase in T-ALL growth.