PIM1 and acute lymphoblastic leukemia: To better understand the role of PIM kinases in T-ALL growth and to assess the potential application of PIM inhibitors in the treatment of T-ALL, we analyzed the effects of two structurally different pan-PIM kinase inhibitors on T-ALL cell lines and carried out a gene profiling analysis using a publically available T-ALL patient dataset Our results demonstrated that PIM kinases are highly overexpressed in the majority of ETP-ALL and in some percentage of non-ETP ALL patient samples.