SPS1, aside from selenocysteine biosynthetic processes in human lung adenocarcinoma cells [25], and it has been reported to be involved in various physiological processes in conjunction with selenoproteins like imaginal disc development [37], cell proliferation [38], mitochondrion organization [39], glutaminemetabolism [40], stress responses [41], negative regulation of ROS homeostasis [42], and even neurogenesis [43]. The gene discussed is SEPHS1; the disease is lung adenocarcinoma.