To assess whether mir-17~92 deletion impairs progression to carcinoma, we accelerated the KC model by including conditional loss of one copy of Trp53 (LSL-KrasG12D, Trp53flox/wt, Ptf1a-Cre and mir-17~92flox/flox, LSL-KrasG12D, Trp53flox/wt, Ptf1a-Cre; hereafter “KPC” and “17KPC” mice). Here, TP53 is linked to keratoconus.