ALK and non-small cell lung carcinoma: The aim of the present study was to: i) implement a centralized NGS-based framework in the southern health care region of Sweden, Scandinavia, corresponding to one of the larger decentralized healthcare regions in Sweden, for clinical analysis of treatment predictive mutations in NSCLC, ii) determine the potential diagnostic yield of the NGS testing based on a complete year of clinical analysis, and iii) to investigate the clinical potential of multiplexed gene fusion analysis of ALK, RET, and ROS1 based on RNA expression (Figure 1).