PTEN and adenocarcinoma: Associations between mutation status for individual genes and clinicopathological variables (age, gender, and tumor histology) were scarce, with exception for BRAF (adenocarcinoma histology), EGFR (adenocarcinoma histology), KRAS (younger age, gender, adenocarcinoma histology), CTNNB1 (gender), PTEN (adenocarcinoma histology), STK11 (adenocarcinoma histology), and TP53 (adenocarcinoma histology) (Supplementary Figure 1).