Consistent with the finding of this study, multiple reports have showed that plasma FAPα levels were lower in cancer patients compared with healthy volunteers [4, 8, 27], and decline level of circulating FAPα even presented in pancreatic ductal adenocarcinoma which drives formation of the fibroblast-rich desmoplastic stroma [22]. The gene discussed is FAP; the disease is pancreatic ductal adenocarcinoma.