The plasma FAPα level was able to distinguish ESCC patients (n = 151) from healthy controls (n = 194) and the benign ESCC (n = 36) with an AUC based on a ROC analysis (AUC = 0.714), whereas the AUCs of the traditional biomarkers of CEA, CYFRA211 and SCCA were 0.549, 0.628, and 0.653, respectively (Figure 2A). Here, FAP is linked to esophageal squamous cell carcinoma.