More than 50% of the cells in the papillomas of vehicle control treated mice contained nuclear Hmga2 (Figure 2J, 2K), while in panobinostat treated mice, there were either no or lower levels of Hmga2 protein in the nucleus, and in some cells Hmga2 was detected in the membrane (Figure 2L and 2M–2Mi). Here, HMGA2 is linked to papilloma.