S100A8 and gastric cancer: In summary, of the environmental and genetic factors evaluated in this study, logistic regression analysis identified H. pylori infection with CagA strains (OR: 1.99; 95% CI: 1.55–2.54), smoking habit (OR: 1.77; 95% CI: 1.22–2.57), and positive family history of GC (OR: 2.87; 95% CI: 1.85–4.45) as independent risk factors for the development of GC.