S100A8 and infection: Among the evaluated features, infection with H. pylori and CagA+ strains was significantly associated with a higher risk of GC (H. pylori, odds ratio (OR): 1.38; 95% confidence interval (CI): 1.09–1.76; P = 0.008; CagA+ strains, OR: 1.95; 95% CI: 1.54–2.46; P < 0.0001).