PVT1 and Familial prostate cancer: It has been reported that lncRNAs could adjust the methylation status of target genes, such as LncRNA PVT1 regulates prostate cancer cell growth by inducing methylation of miR-146a, LncRNA DBCCR1–003 regulates methylation of DBCCR1 via DNMT1 in bladder cancer, and LncRNA RP5–833A20.1 induces methylation of NFIA in U251 cells [32–34].