CDKN2B and neoplasm: Among 30 deletion events in T and 39 in B regions, PTX4 (16p13.3), KIF20B (10q23.31), SYCP2 (20q13.33) and 9p21.3 (CDKN2A and CDKN2B, MTAP) were prominent in both T and B. These results confirm that alterations of the genome play a central role for tumor cell proliferation in T and B. Further, transcriptome changes observed in SL might be predominantly driven by other mechanisms (e.g. epigenetics) and potentially induced by the chronic inflammation as well as the tumor-microenvironment cross-talk.