This was further supported by treatment with the microtubuli-stabilizing agent taxol, which could efficiently halt the melanoma cells in M-phase, visualized by a G2/M arrest in cell cycle analyses after a 16 h-treatment, and correlated with elevated PT359/S363-RSK and PS102-YB-1 levels (Supplementary Figure 4A, 4B). This evidence concerns the gene RPS6KA1 and melanoma.