As we could confirm the importance of RSK activity to sustain the inactivating S112-phosphorylation in MAPK inhibitor resistant melanoma cells and observed an induction of apoptotic cell death after chronic application of RSK inhibitors, the detrimental effect of RSK inhibition in these cells could – at least partly – be mediated by active pro-apoptotic Bad. Here, RPS6KA2 is linked to melanoma.