Recently, a series of CAR-NK-92 cell lines were generated, including CD3-CAR-NK-92 for peripheral T-cell lymphomas (PTCLs) [6], EGFR-CAR-NK-92 for breast cancer [34], and CD138 or CS1-CAR-NK-92 for multiple myeloma (MM) [29, 35]. Here, SDC1 is linked to breast carcinoma.