As fore- mentioned that CAD risk was influenced by many gene polymorphisms or interactions among several genes, considering CYP1A1 and PPARG both are risk factor of CAD, however, to date, less study focused on PPAR G- CYP1A1 interaction on CAD risk was reported, so the aim of this study was to investigate the impact of PPARG and CYP1A1 polymorphisms, and synergistic interaction between the two genes on CAD risk. This evidence concerns the gene PPARA and coronary artery disorder.