In this sense, considering that low JHDM1B expression levels were found in aggressive brain and breast tumors characterized by an abnormally amplified ribosome biogenesis, we hypothesized that, despite its suppressive activity on proliferative senescence, the downregulation of this histone demethylase might contribute to tumor aggressiveness [2, 15]. The gene discussed is KDM2B; the disease is neoplasm.