Accumulating evidence supports the notion that RT triggers strong proimmunogenic effects with increased expression of both proinflammatory and anti-inflammatory/immune-tolerant cytokines produced by both tumor cells and murine stromal cells, including IL-1β, tumor necrosis factor (TNF)-α, TGF-β, IL-6, IL-8, and IL-10 (reviewed in Leroi et al. 2016 [43]). This evidence concerns the gene IL1B and neoplasm.