ERBB2 and esophageal adenocarcinoma: This report evaluates the therapeutic effect of cetuximab (anti-EGFR) and trastuzumab (anti-HER2) targeted NIR-tPDT in Esophageal adenocarcinoma in vitro and, as a first, describes modulation of the EGFR and HER2 receptors with use of TKIs, as a tool to enhance the therapeutic effect and applicability of NIR-tPDT.