EGFR and non-small cell lung carcinoma: A dramatic reduction in the extent of EGFR phosphorylation occurs in cells, when conditioned medium from NSCLC cells is denatured or depleted of EGFR ligands with a soluble EGFR trap, demonstrating that PGE2 promotes EGFR activation and internalization through cleavage of membrane-bound EGFR ligands.