Notably, cycloxigenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGES-1), the two inducible key enzymes in PGE2 biosynthesis, were found overexpressed in NSCLC, correlating with the reduced survival in patients with stage I disease [5–7]. This evidence concerns the gene PTGES and non-small cell lung carcinoma.