In tumor cells treated with PGE2 for 60 min the levels of AREG and EREG increased, whereas in the presence of c-SRC inhibitors (PP1 or SU6656) or ADAM-MMPs inhibitor (GM6001), AREG and EREG levels declined towards the baseline (Figure 10D and 10E, Supplementary Figure 11D and 11E). This evidence concerns the gene AREG and neoplasm.