The multiple confocal immunofluorescence, confirmed the presence of tumor vessels lined by FVIII+ endothelial cells (Figure 6A–6C red signal) and expressing both pStat3 (Figure 6A, 6B, 6D green signal) and CD133 (Figure 6A, 6C, 6D blue signal). The gene discussed is PROM1; the disease is neoplasm.