Given the fact that MMP-2 and MMP-9 inhibitors significantly reduced the severity of renal tubule damage and suppressed the development of AKI after ischemia-reperfusion [44], we propose that Src may also aid in reducing epithelial and endothelial permeability and subsequent kidney damage by attenuating activity of these two proteinases. This evidence concerns the gene MMP9 and Nephropathy.