In this study, we report a novel role for the late endosomal protein Rab7 GTPase in the regulation of the selective recruitment of tyrosine 118 (Y118)-phosphorylated paxillin, but not Y31-phospho-paxillin to autophagosomes via its interaction with c-Cbl, which serves as a cargo receptor independently of its E3 ubiquitin ligase activity, in human breast cancer cells. The gene discussed is CBL; the disease is breast cancer.