In this 134 CRC patients cohort, immunohistochemical results revealed that CXCR2 expression was upregulated in 61.2% (82/134) tissues of overall cohort, 57.7% (45/78) tissues in training set and 66.1% (37/56) tissues in validation set. The gene discussed is CXCR2; the disease is colorectal carcinoma.