Consistently, the promotion effect of circulating B16F0 cells on the metastatic colonization of disseminated B16F1 cells was also suppressed by sTLR2 and sTLR4 (Figure 6G), further confirming that TLR2/4 ligands are the main inflammatory stimuli that are responsible for promoting tumor metastasis by CTCs. This evidence concerns the gene TLR2 and neoplasm.