IL-12B rs3212227 was proved to enhance overall cancer risk (C vs. A: OR = 1.15, 95%CI: 1.05-1.25; CC vs. AA: OR = 1.32, 95%CI: 1.11-1.56; AC vs. AA: OR= 1.21, 95%CI: 1.08-1.35, P = 0.001; AC+CC vs. AA: OR = 1.24, 95%CI: 1.10-1.40, P < 0.001; CC vs. AC+AA: OR = 1.17, 95%CI: 1.04-1.31). Here, IL12B is linked to cancer.