In order to test if the bearing of a subcutaneous melanoma tumor and/or the presence of melanoma micrometastasis in the brain leads to alterations in the expression of CCR4 ligands in this organ, we measured the expression of the CCR4 ligands in the brain at different time points following a subcutaneous inoculation of HBMMC to nude mice. The gene discussed is CCR4; the disease is melanoma.