Therefore, we initially performed functional annotations of ARID1B variants using the bioinformatics tools, HaploReg V4.1 [18] and PolyPhen-2 [19], and then conducted a case-control study, including 611 cases and 614 controls, to explore the effect of three ARID1B potentially functional variants (rs73013281C>T, rs167007A>G, and rs9397984C>T) and their interaction with lifestyle on HCC incidence in a Southern Chinese population. The gene discussed is ARID1B; the disease is hepatocellular carcinoma.