Importantly, multiple studies utilizing next-generation sequencing technology have revealed that ARID1B was frequently mutated in a subset of cancers, including prostate, gastric, colorectal and liver cancers [2, 7, 11, 12], among which, a recent whole-genome sequencing (WGS) analysis of hepatocellular carcinoma (HCC) has listed ARID1B as one of recurrently mutated genes [2]. The gene discussed is ARID1B; the disease is hepatocellular carcinoma.