KRAS and Familial prostate cancer: In current study, we further demonstrated the underlying mechanisms by which the co-suppression of PKC α and β appeared essential for the viability of pancreatic cancer cells harboring mutated K-ras or prostate cancer cells expressing active Akt. The data suggested that these two PKC isoforms coped with aberrant Ras or Akt to keep the homeostasis in the cancer cells.