To further explore the molecular mechanisms by which 2-DG induces cell death and GC sensitivity in ALL, we examined the expression of HKII and critical signaling proteins associated with energy metabolism in general (AMP-activated protein kinase, AMPKα and p-AMPKα), ER stress marker (glucose-regulated protein 78, GRP78), p70S6 kinase (p70S6K), p- p70S6K and cell apoptosis in Molt-4 cells. This evidence concerns the gene HSPA5 and acute lymphoblastic leukemia.