SS-onset SLE were significantly older, showed a higher frequency of Raynaud's phenomenon, anti-SSA and anti-SSB, a lower frequency of severe renal involvement and lower mortality, and presented comparatively stable disease course and benign prognosis that required less vigorous treatment with glucocorticoids and/or immunosuppressant when compared with SLE-only patients [5, 11, 12]. The gene discussed is SSB; the disease is systemic lupus erythematosus.