Positive HK2 expression was correlated with certain phenotypes of tumor aggressiveness, such as large tumor size (pooled odd ration [OR] = 2.03; 95% CI = 1.10–3.74; P = 0.024; random effects), positive lymph node metastasis (pooled OR = 2.05; 95% CI = 1.39–3.02; P < 0.001; fixed effects), advanced clinical stage (pooled OR = 2.17; 95% CI = 1.21–3.89; P = 0.009; random effects) and high alpha fetoprotein (AFP) level (pooled OR = 1.47; 95% CI = 1.09–2.02; P = 0.013; fixed effects). This evidence concerns the gene AFP and neoplasm.