But for the individuals with APOE ε4-negative genotype (APOE ε4-), there was large heterogeneity (I2 = 81.5, Table 2) under the allelic model, and no significant association between the rs242557 SNP with AD risk (OR = 1.29, 95% CI = 0.93, 1.80, P = 0.132, Table 3, Figure 4). This evidence concerns the gene APOE and Alzheimer disease.