For instance, Gadofosveset is a Gd-based contrast agent that can bind reversibly to albumin thereby prolonging its vascular presence and increasing its relativity (r1) by 5 to 10 fold, however, when Gadofosveset was tested for assessing endothelial permeability in atherosclerosis it could not detect significant differences between normal and tumour vessels and showed low enhancement [60]. This evidence concerns the gene ALB and neoplasm.