Zeng et al compared Gd-DTPA and albumin-binding Gd-EOB-DTPA for assessing microvessel characteristics with DCE-MRI in a murine orthotropic pancreatic cancer model and found that the tumor rim could be distinguished from the tumor core by Gd-EOB-DTPA but not Gd-DTPA, which was consistent with immunohistology data showing that CD31 and VEGF expression in the tumor rim was significantly higher than in the core [17]. This evidence concerns the gene PECAM1 and neoplasm.