UCA1 and melanoma: Knockdown of UCA1 in A375 and SK-MEL-2 cell lines decreased the number of invasive melanoma cells and increased the fraction of G0/G1 phase cells.[63] In addition, in vitro studies by Tian et al.[62] revealed that A375 cells with reduced expression of UCA1 lncRNA, migrated less effectively through a transwell assay.