HOTAIR and melanoma: HOX antisense intergenic RNA (HOTAIR) is transcribed from the HOXC cluster and recruits PRC2 to specific target genes, leading to H3K27 trimethylation and epigenetic silencing of metastatic suppressor genes.[18, 68, 69] HOTAIR deregulation is associated with prometastatic activity in melanoma [70–72], but also in breast cancer, [69] cervical cancer [73] and pancreatic cancer.[74] HOTAIR has been suggested to stimulate the degradation of extracellular matrix through the activation of matrix metalloproteinases.[70]