RNAi-dependent knockdown of BANCR inhibited melanoma cell migration by upregulating the chemokine CXCL11, a regulator of cell migration.[44] BANCR is also capable to promote melanoma proliferation by activating the ERK1/2 and JNK MAPK pathways both in vitro and in vivo in a mouse model.[45] More recently, upregulated BANCR expression has also been reported in retinoblastoma,[46] colorectal cancer [47] and gastric cancer.[48] In contrast, BANCR was downregulated in non small cell lung cancer (NSCLC).[49]. This evidence concerns the gene MAPK3 and melanoma.