GAS5 and hepatocellular carcinoma: GAS5 is presumed to have tumor suppressive potential and is downregulated in multiple malignancies.[77–80] Moreover, reduced GAS5 transcript levels in tumor tissue are associated with lymph node metastasis in cervical cancer [81] and hepatocellular cancer.[82] Chen et al.[80] detected the expression of GAS5 among five human melanoma cell lines.