SPRY4 and esophageal squamous cell carcinoma: Besides melanoma, SPRY4-IT1 has been reported to play an important role in esophageal squamous cell carcinoma,[36] prostate cancer,[37] glioma[38] and gastric cancer.[39] Mazar et al.[40] suggested that SPRY4-IT1 inhibits apoptosis via binding to LPIN2, thus altering lipid metabolism by avoiding cellular lipotoxicity.