ISLR/Meflin is a newly discovered surface and secreted pluripotency-related protein [23] whose over-expression has been described in cancer stroma [43] and fibrotic diseases, and a recent immunoprecipitation study has demonstrated its interaction with receptor tyrosine kinases (RTKs) such as EGFR and PDGFRA [34]. This evidence concerns the gene PDGFRA and cancer.