This system consists of modules of TF-TF or miRNA-TF pairs (the latter is also known as the chimera module) that can regulate decisions concerning the fate of cancer cells, and it is expected that the cancer cell state corresponds to the result of a mutually inhibitory pair of TF-TF or miRNA-TF genes, in which one or both genes are self activating, thus respectively leading to asymmetric or symmetric activation. This evidence concerns the gene TF and cancer.